Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries

@article{Satoh2004DifferentialAB,
  title={Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries},
  author={K. Satoh and H. Yamada and N. Taira},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={343},
  pages={76-82}
}
SummaryThe relaxant mechanisms of action of cromakalim, pinacidil and nicorandil, potassium channel openers, on large epicardial coronary arteries were investigated in isolated canine left circumflex arteries contracted by 10−7 mol/l U46619, a thromboxane A2 analogue, or addition of 25 mmol/l KCl in comparison with nitroglycerin.Cromakalim (3 × 10−8−3 × 10−5 mol/l), pinacidil (10−6−10−4 mol/l), nicorandil (3 × 10−6−10−3 mol/l) and nitroglycerin (3 × 10−8−10−5 mol/l) all produced a concentration… Expand
Nicorandil as a nitrate, and cromakalim as a potassium channel opener, dilate isolated porcine large coronary arteries in an agonist-nonselective manner
TLDR
The results indicate that the vasorelaxant actions of nicorandil and cromakalim in the porcine large coronary artery are agonist nonselective and that nicor andil exerts such an action entirely as a nitrate, whereas cromkalim does so entirely asA potassium channel opener. Expand
Mechanism of the vasodilatory action of nicorandil on coronary circulation in dogs
TLDR
It is suggested that nicorandil-induced dilatation of the large coronary arteries was related to its nitrate action, while nicor andil- induced dilatations of the small coronary artery was closely related toIts effect as a K+ channel opener. Expand
The group at C2 of N-ethylnicotinamide determines the vasodilator potencies and mechanisms of action of nicorandil and its congeners in canine coronary arteries
TLDR
The results indicate that the group at C2 of the parent structure of nicorandil and its congeners, i.e., N-ethylnicotinamide determines not only the vasodilator potency but the vasODilator mechanism of action of the compound. Expand
Potassium channel opener pinacidil induces relaxation of the isolated human radial artery.
TLDR
Pinacidil induces relaxation of the human RA in endothelium-independent manner, and glibenclamide- and TEA-sensitive vascular smooth muscle K+ channels are probably involved. Expand
Interspecies Differences and Extracellular Calcium Dependence in the Vasorelaxing Effect of Cromakalim in Isolated Human, Porcine, and Canine Coronary Arteries
TLDR
It appears that the coronary dilating effect of cromakalim largely depends on the species and is modulated by [Ca2+]o, with a partly endothelium dependent manner. Expand
A further study of the vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners in the canine heart
TLDR
It is indicated that both nicorandil and SG-209 act as K-channel openers in coronary resistance vessels and in ventricular myocardium, and that the nitroxyl and the acetoxyl group at C2 of the parent structure of nicor andil and its congeners play a pivotal role in making these compounds act asK- channel openers. Expand
Myocardial protection of immature rabbits: polarizing versus depolarizing.
TLDR
Pinacidil provided better protection during ischemia-reperfusion in the immature rabbit heart than St.Thomas' solution, whereas pinacidil combined with St. Thomas' solution showed the worst protective effects in immature hearts. Expand
Anti-free-radical and neutrophil-modulating properties of the nitrovasodilator, nicorandil
TLDR
Nicorandil is a uniquely different nitrovasodilator with anti-free-radical and neutrophil-modulating properties. Expand
Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles
TLDR
A relatively potent relaxant effect of curcumin is indicated on tracheal smooth muscle (TSM) which was less marked than the effect of theophylline and may be responsible for TSM relaxation. Expand
Relaxant effect of Curcuma longa on rat tracheal smooth muscle and its possible mechanisms
TLDR
Tracheal smooth muscle relaxant effects of C. longa, were comparable to those of theophylline, which could be due to the presence of methylxanthines or its possible interaction with non-adrenergic non-cholinergic nervous system. Expand
...
1
2
...

References

SHOWING 1-10 OF 32 REFERENCES
Vasorelaxant effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels.
TLDR
Cromakalim posseses a novel mechanism of vasorelaxation that is consistent with the activation of a cellular outward K+ current and was accompanied by decreases in systemic, hindquarter, mesenteric, and renal vascular resistances. Expand
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
  • M. Eltze
  • Chemistry, Medicine
  • European journal of pharmacology
  • 1989
TLDR
The results suggest that the vascular relaxation caused in guinea-pig pulmonary artery by cromakalim, pinacidil and RP 49356 is mediated through the same glibenclamide-sensitive K+ channel whereas the major mechanism for the effect of nicorandil seems to involve stimulation of guanylate cyclase. Expand
Specific but differential antagonism by glibenclamide of the vasodepressor effects of cromakalim and nicorandil in spinally‐anaesthetized dogs
TLDR
The results suggest that the vasodepressor action of cromakalim is due predominantly to potassium channelOpening, but that of nicorandil involves not only potassium channel opening but its action as a nitrate. Expand
Inhibition by glibenclamide of the vasorelaxant action of cromakalim in the rat
TLDR
The results suggest that the vasorelaxant and hypotensive actions of cromakalim involve a K- channel which can be inhibited by glibenclamide, but which may be distinct from the ATP‐sensitive K+ channel of the pancreatic β‐cell. Expand
Nicorandil increases coronary blood flow predominantly by K-channel opening mechanism
TLDR
The results indicate that the effect of nicorandil in increasing coronary blood flow, like that of cromakalim, is predominantly due to its mechanism of action as a K-channel opener. Expand
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil
TLDR
Results show that cromakalim is a more specific K+ channel opener than pinacidil and nicorandil, and that vasodilatation produced by cromkalim in this study is predominantly a result of a reduction of [Ca2+]i due to the closure of voltage‐dependent Ca2+ channels by hyperpolarization. Expand
Phentolamine and structurally related compounds selectively antagonize the vascular actions of the K+ channel opener, cromakalim
TLDR
It is suggested that phentolamine and some structurally related compounds, may inhibit K+ channel opening, an action which would account for their ability to antagonize the actions of cromakalim. Expand
Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil.
TLDR
The results confirm the role of K+ channel activation in vasorelaxation to cromakalim, pinacidil and nicorandil, but suggest that additional mechanisms may be involved for pinacidIL and, in particular, for nicor andil. Expand
Cyclic GMP as Possible Mediator of Coronary Arterial Relaxation by Nicorandil (SG‐75)
  • S. Holzmann
  • Chemistry, Medicine
  • Journal of cardiovascular pharmacology
  • 1983
TLDR
Results indicate that nicorandil relaxes vascular smooth muscle, at least in part, through cGMP, which is likely to be mediated by cyclic GMP. Expand
Specificity of action of the novel antihypertensive agent, BRL 34915, as a potassium channel activator. Comparison with nicorandil.
TLDR
Evidence is lent support to other evidence suggesting that BRL 34915 relaxes vascular smooth muscle (and hence lowers blood pressure) by a novel, and specific, mechanism involving hyperpolarisation of the smooth muscle cell membrane. Expand
...
1
2
3
4
...