Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails

@article{Niu2010DifferentialAR,
  title={Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails},
  author={Yi Feng Niu and T-M Chang and Starla Yeh and W-L Maverick Ma and Yue Zeng Wang and Chi-Ching Chang},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={3593-3604}
}
Prostate cancer is one of the major causes of cancer-related death in the western world. Androgen-deprivation therapy (ADT) for the suppression of androgens binding to the androgen receptor (AR) has been the norm of prostate cancer treatment. Despite early success to suppress prostate tumor growth, ADT eventually fails leading to recurrent tumor growth in a hormone-refractory manner, even though AR remains to function in hormone-refractory prostate cancer. Interestingly, some prostate cancer… CONTINUE READING
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