Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions.

@article{Trapani2016DifferentialAT,
  title={Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions.},
  author={Mariano Di Trapani and Giulio Bassi and Martina Midolo and Alessandro Gatti and Paul Takam Kamga and Adriana Cassaro and Roberta Carusone and Annalisa Adamo and Mauro Krampera},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={24120}
}
Mesenchymal stromal cells (MSCs) are multipotent cells, immunomodulatory stem cells that are currently used for regenerative medicine and treatment of a number of inflammatory diseases, thanks to their ability to significantly influence tissue microenvironments through the secretion of large variety of soluble factors. Recently, several groups have reported the presence of extracellular vesicles (EVs) within MSC secretoma, showing their beneficial effect in different animal models of disease… CONTINUE READING
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