Differential analysis between somatic mutation and germline variation profiles reveals cancer-related genes

Abstract

A major aim of cancer genomics is to pinpoint which somatically mutated genes are involved in tumor initiation and progression. We introduce a new framework for uncovering cancer genes, differential mutation analysis, which compares the mutational profiles of genes across cancer genomes with their natural germline variation across healthy individuals. We… (More)
DOI: 10.1186/s13073-017-0465-6

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