Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.

@article{Nagy2003DifferentialAI,
  title={Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.},
  author={J{\'o}zsef Nagy and S{\'a}ndor Kolok and P{\'e}ter Dezso and Andr{\'a}s Boros and Zsolt Szombathelyi},
  journal={Neurochemistry international},
  year={2003},
  volume={42 1},
  pages={35-43}
}
In our previous experiments, severe cellular damages and neuronal cell loss were observed following 24h of alcohol withdrawal in primary cultures of rat cortical neurones pre-treated with ethanol (50-200 mM) repeatedly for 3 days. Increased NMDA induced cytosolic calcium responses and excitotoxicity were also demonstrated in the ethanol pre-treated cultures. Thus, the enhancement in functions of NMDA receptors was supposed to be involved in the adaptive changes leading to the neurotoxic effect… CONTINUE READING

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