Differential alteration of striatal D-1 and D-2 receptors induced by the long-term administration of haloperidol, sulpiride or clozapine to rats.

@article{Jenner1985DifferentialAO,
  title={Differential alteration of striatal D-1 and D-2 receptors induced by the long-term administration of haloperidol, sulpiride or clozapine to rats.},
  author={P Feroz Jenner and Nadia M. J. Rupniak and C. David Marsden},
  journal={Psychopharmacology. Supplementum},
  year={1985},
  volume={2},
  pages={174-81}
}
Rats received haloperidol, sulpiride, or clozapine in their daily drinking water for up to 1 year in clinically equivalent doses. After 12 months' drug intake, and while drug administration continued, striatal dopamine function was assessed. Haloperidol induced D-2 receptor hypersensitivity as shown by enhanced apomorphine-induced stereotypy, elevated Bmax… CONTINUE READING