Differential allelic expression in leukoblast from patients with acute myeloid leukemia suggests genetic regulation of CDA, DCK, NT5C2, NT5C3, and TP53.

@article{Jordheim2008DifferentialAE,
  title={Differential allelic expression in leukoblast from patients with acute myeloid leukemia suggests genetic regulation of CDA, DCK, NT5C2, NT5C3, and TP53.},
  author={Lars Petter Jordheim and Tu Nguyen-Dumont and X. Thomas and Charles Dumontet and Sean V. Tavtigian},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2008},
  volume={36 12},
  pages={2419-23}
}
mRNA expression levels of certain genes have shown predictive value for the outcome of cytarabine-treated AML-patients. We hypothesized that genetic variants play a role in the regulation of the transcription of these genes. We studied leukoblasts from 82 patients with acute myeloid leukemia and observed various extent and frequency of differential allelic expression in the CDA, DCK, NT5C2, NT5C3, and TP53 genes. Our attempts to identify the causative regulatory single nucleotide polymorphisms… CONTINUE READING

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