Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland.

@article{Takekida2000DifferentialAR,
  title={Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland.},
  author={Shigeki Takekida and Lily Yan and Elizabeth S. Maywood and Michael H Hastings and Hitoshi Okamura},
  journal={The European journal of neuroscience},
  year={2000},
  volume={12 12},
  pages={4557-61}
}
Precise temporal regulation of transcription is pivotal to the role of the mammalian pineal gland as a transducer of circadian and seasonal information. The circadian clock genes Per1 and Per2 encode factors implicated in temporally gated transcriptional programmes in brain and pituitary. Here we show that the nocturnal circadian expression of Per1 and Per2 in the rat pineal gland parallels that of serotonin N-acetyltransferase (NAT) mRNA, which encodes the rate-limiting enzyme of melatonin… CONTINUE READING

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