Differential adaptation of glucocorticoid sensitivity of peripheral blood mononuclear leukocytes in patients with sepsis or septic shock.

@article{Molijn1995DifferentialAO,
  title={Differential adaptation of glucocorticoid sensitivity of peripheral blood mononuclear leukocytes in patients with sepsis or septic shock.},
  author={G J Molijn and Janneke J. Spek and J C van Uffelen and Frank H. de Jong and Albert O. Brinkmann and Hajo A. Bruining and Steven W. J. Lamberts and Jan Willem Koper},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1995},
  volume={80 6},
  pages={1799-803}
}
In view of the immunosuppressive action of glucocorticoids (GCs), the activation of the hypothalamo-pituitary-adrenal axis in patients with sepsis or septic shock is paradoxical. At the same time, administration of GCs to these patients is not clearly beneficial. We investigated the role of GCs in severe illness by measuring the sensitivity of peripheral blood mononuclear leukocytes to GCs in a mitogen-stimulated lymphocyte proliferation assay. In addition, we studied the role of interleukin-2… CONTINUE READING
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