Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine

@article{Poul2000DifferentialAO,
  title={Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine},
  author={Emmanuel Le Poul and Claudette Boni and Naı̈ma Hanoun and A. M. Laporte and Laurence Lanfumey},
  journal={Neuropharmacology},
  year={2000},
  volume={39},
  pages={110-122}
}
Quantification of receptor binding sites and their encoding mRNAs, and electrophysiological recordings, were used to assess central serotonin (5-HT) neurotransmission in rats 24 h after a 2-3 week treatment with the selective 5-HT reuptake inhibitor fluoxetine (8 mg/kg i.p., daily). Binding studies showed that this treatment affected neither 5-HT1A nor 5-HT1B binding sites in all brain areas examined. However, a significant decrease (-38%) in 5-HT1A mRNA levels in the anterior raphe area (but… CONTINUE READING

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  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2001
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