Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury.

  title={Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury.},
  author={Uwe Scherbel and Ramesh Raghupathi and Mamoo Nakamura and Kathryn E. Saatman and John Q. Trojanowski and Edmund A G Neugebauer and Michael W. Marino and T K Mcintosh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 15},
The present study evaluated behavioral and histopathological outcome after controlled cortical impact (CCI) brain injury in mice deficient in tumor necrosis factor [TNF(-/-)] and their wild-type (wt) littermates. Mice were subjected to CCI brain injury [TNF(-/-), n = 10; wt, n = 10] or served as uninjured controls [TNF(-/-), n = 10; wt, n = 10] and were evaluated for deficits in memory retention at 7 days postinjury. Although both brain-injured wt and TNF(-/-) mice exhibited significant memory… CONTINUE READING
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