Differential activity of bone marrow hematopoietic stem cell subpopulations for EPC development and ischemic neovascularization.

@article{Kwon2011DifferentialAO,
  title={Differential activity of bone marrow hematopoietic stem cell subpopulations for EPC development and ischemic neovascularization.},
  author={Sang-Mo Kwon and Yun-Kyung Lee and Ayumi Yokoyama and Seok-Yun Jung and Haruchika Masuda and Atsuhiko Kawamoto and You Mie Lee and Takayuki Asahara},
  journal={Journal of molecular and cellular cardiology},
  year={2011},
  volume={51 3},
  pages={308-17}
}
Although endothelial progenitor cells (EPCs) differentiate from minor populations of stem cells in bone marrow (BM), the differential role of hematopoietic stem cell (HSC) subpopulations in EPC development is largely unclear. Morphological characterization of EPC colonies has revealed that c-kit+/Sca-1+/lineage (Lin)-(KSL) cells mainly develop small EPC-colony forming units (CFUs) not large EPC-CFUs. In contrast, c-kit+/Sca-1-/Lin- (KL) cells develop large EPC-CFUs not small EPC-CFUs. Neither c… CONTINUE READING

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AkimaruH,KurataH.Bonemarrowsubpopulations contain distinct types of endothelial progenitor cells and angiogenic cytokineproducing cells

  • MiyamotoY, SuyamaT, T Yashita
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1 Excerpt

Bonemarrowsubpopulations contain distinct types of endothelial progenitor cells and angiogenic cytokineproducing cells

  • SuyamaT MiyamotoY, T Yashita, KurataH AkimaruH
  • J Mol Cell Cardiol
  • 2007

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