Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats.

@article{Wegert1997DifferentialAO,
  title={Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats.},
  author={Sandra Wegert and Michael H. Ossipov and Mary L. Nichols and Di Bian and Todd W. Vanderah and T. Philip Malan and F rank Porreca},
  journal={Pain},
  year={1997},
  volume={71 1},
  pages={57-64}
}
Nerve ligation injury in rats results in reduced nociceptive and non-nociceptive thresholds, similar to some aspects of clinical conditions of neuropathic pain. Since underlying mechanisms of hyperalgesia and allodynia may differ, the present study investigated the pharmacology of morphine and MK-801 in rats subjected to a tight ligation of the L5 and L6 nerve roots or to a sham-operation procedure. Response to acute nociception was measured by (a) withdrawal of a hindpaw from a radiant heat… CONTINUE READING