Differential activation requirements for virgin and memory T cells.

  title={Differential activation requirements for virgin and memory T cells.},
  author={Jennifer A. Byrne and Joseph L. Butler and Max D. Cooper},
  journal={Journal of immunology},
  volume={141 10},
Most studies of the activation requirements for T cells have used either T cell lines or populations of normal T cells that consist of a mixture of virgin and Ag-primed T cells. These two subpopulations of T cells can now be distinguished in humans by their reactivity with mAb. The anti-CD45R antibody HB10 identifies virgin T cells (T degrees) that are non-reactive to recall Ag and relatively poor at providing help for B cell differentiation. Conversely, memory T cells (T') that can react to… CONTINUE READING

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