Differential activation pattern of redox-sensitive transcription factors and stress-inducible dilator systems heme oxygenase-1 and inducible nitric oxide synthase in hemorrhagic and endotoxic shock.

@article{Rensing2001DifferentialAP,
  title={Differential activation pattern of redox-sensitive transcription factors and stress-inducible dilator systems heme oxygenase-1 and inducible nitric oxide synthase in hemorrhagic and endotoxic shock.},
  author={Hauke Rensing and Hartmut Jaeschke and Iwona Bauer and C P{\"a}tau and V Datene and Benedikt H. J. Pannen and Michael D. Bauer},
  journal={Critical care medicine},
  year={2001},
  volume={29 10},
  pages={
          1962-71
        }
}
OBJECTIVE To investigate the role of redox-sensitive transcription factors nuclear factor kappa-B (NF-kappaB) or activator protein-1 (AP-1) for hepatic gene expression of heme oxygenase (HO)-1 and inducible nitric oxide synthase (iNOS) in models of hemorrhagic or endotoxic shock. DESIGN Prospective controlled laboratory study. SETTING Animal research laboratory at a university hospital. SUBJECTS Male Sprague-Dawley rats (250-350 g). INTERVENTIONS After anesthesia, animals were assigned… CONTINUE READING
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