Differential activation of the tcpPH promoter by AphB determines biotype specificity of virulence gene expression in Vibrio cholerae.

@article{Kovacikova2000DifferentialAO,
  title={Differential activation of the tcpPH promoter by AphB determines biotype specificity of virulence gene expression in Vibrio cholerae.},
  author={Gabriela Kovacikova and Karen Skorupski},
  journal={Journal of bacteriology},
  year={2000},
  volume={182 11},
  pages={3228-38}
}
Vibrio cholerae strains of the classical biotype express the genes encoding cholera toxin (CT) and toxin-coregulated pilus (TCP) under a variety of environmental conditions in vitro, whereas El Tor biotype strains express these genes only under specialized culture conditions. We show here that a single base-pair difference at positions -65 and -66 of the classical and El Tor tcpPH promoters, respectively, is responsible for the differential regulation of virulence gene expression in these two… CONTINUE READING

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