Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

  title={Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf},
  author={Sanjeev Mariathasan and Kim Newton and Denise M Monack and Domagoj Vucic and Dorothy M. French and Wyne P Lee and Meron Roose-Girma and Sharon S. Erickson and Vishva M. Dixit},
Specific adaptors regulate the activation of initiator caspases; for example, FADD and Apaf-1 engage caspases 8 and 9, respectively. The adaptors ASC, Ipaf and RIP2 have each been proposed to regulate caspase-1 (also called interleukin (IL)-1 converting enzyme), which is activated within the ‘inflammasome’, a complex comprising several adaptors. Here we show the impact of ASC-, Ipaf- or RIP2-deficiency on inflammasome function. ASC was essential for extracellular ATP-driven activation of… CONTINUE READING
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