Differential activation of the NF-kappaB-like factors Relish and Dif in Drosophila melanogaster by fungi and Gram-positive bacteria.

@article{HedengrenOlcott2004DifferentialAO,
  title={Differential activation of the NF-kappaB-like factors Relish and Dif in Drosophila melanogaster by fungi and Gram-positive bacteria.},
  author={Marika Hedengren-Olcott and Michael C. Olcott and Duane T Mooney and Sophia Ekengren and Bruce L. Geller and Barbara J. Taylor},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 20},
  pages={
          21121-7
        }
}
The current model of immune activation in Drosophila melanogaster suggests that fungi and Gram-positive (G(+)) bacteria activate the Toll/Dif pathway and that Gram-negative (G(-)) bacteria activate the Imd/Relish pathway. To test this model, we examined the response of Relish and Dif (Dorsal-related immunity factor) mutants to challenge by various fungi and G(+) and G(-) bacteria. In Relish mutants, the Cecropin A gene was induced by the G(+) bacteria Micrococcus luteus and Staphylococcus… CONTINUE READING
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