Differential activation of the μ-opioid receptor by oxycodone and morphine in pain-related brain regions in a bone cancer pain model.

@article{Nakamura2013DifferentialAO,
  title={Differential activation of the μ-opioid receptor by oxycodone and morphine in pain-related brain regions in a bone cancer pain model.},
  author={Atsushi Nakamura and Minoru Hasegawa and Kazuhisa Minami and Tomoe Kanbara and Takako Tomii and Atsushi Nishiyori and Minoru Narita and Tsutomu Suzuki and Akira Kato},
  journal={British journal of pharmacology},
  year={2013},
  volume={168 2},
  pages={375-88}
}
BACKGROUND AND PURPOSE Bone cancer pain is chronic and often difficult to control with opioids. However, recent studies have shown that several opioids have distinct analgesic profiles in chronic pain. EXPERIMENTAL APPROACH To clarify the mechanisms underlying these distinct analgesic profiles, functional changes in the μ-opioid receptor were examined… CONTINUE READING