Differential activation of protein kinase C alpha is associated with arachidonate release in Madin-Darby canine kidney cells.

@article{Godson1990DifferentialAO,
  title={Differential activation of protein kinase C alpha is associated with arachidonate release in Madin-Darby canine kidney cells.},
  author={Catherine Godson and B A Weiss and Paul A. Insel},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 15},
  pages={8369-72}
}
The heterogeneity of the protein kinase C (PKC) gene family strongly suggests that different isoforms may have distinct functions in mediating signal transduction. However, there is very little direct evidence for this. PKC has been implicated in arachidonate (AA) release in many cell types. We sought to investigate whether bradykinin- and phorbol ester-stimulated AA release in Madin-Darby canine kidney (MDCK) cells was correlated with differential activation of PKC isoforms. Using phorbol… CONTINUE READING

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