Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest.

Abstract

The ability of p53 to act as a tumor suppressor is tightly correlated with its ability to function as a transcriptional activator at the G1/S-phase cell cycle checkpoint. Previous overexpression studies have indicated simultaneous induction of p53 target genes, despite opposing cellular functions of their protein products. To delineate the response of… (More)

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