Differential activation of orexin neurons by antipsychotic drugs associated with weight gain.

@article{Fadel2002DifferentialAO,
  title={Differential activation of orexin neurons by antipsychotic drugs associated with weight gain.},
  author={Jim R Fadel and Michael Bubser and Ariel Y. Deutch},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 15},
  pages={6742-6}
}
Weight gain is one side effect of many antipsychotic drugs (APDs). A small number of lateral hypothalamic/perifornical area (LH/PFA) neurons express the orexins, peptides that are critically involved in body weight regulation and arousal. We examined the ability of APDs to activate orexin neurons, as reflected by induction of Fos. APDs with significant weight gain liability increased Fos expression in orexin neurons, but APDs with low or absent weight gain liability did not. The weight gain… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS