Differential activation of human gingival epithelial cells and monocytes by Porphyromonas gingivalis fimbriae.

@article{Eskan2007DifferentialAO,
  title={Differential activation of human gingival epithelial cells and monocytes by Porphyromonas gingivalis fimbriae.},
  author={Mehmet Akif Eskan and George Hajishengallis and Denis F. Kinane},
  journal={Infection and immunity},
  year={2007},
  volume={75 2},
  pages={
          892-8
        }
}
Humans develop periodontitis in response to challenge by microbial dental plaque. Inflammation begins after perturbation of gingival epithelial cells by subgingival bacteria interacting through pattern-recognition receptors, including the Toll-like receptors (TLR). Porphyromonas gingivalis is a major periodontopathogen that interacts with epithelial cells through its cell surface fimbriae (FimA), leading to colonization and/or invasion. Previous work by our group has established membrane CD14… CONTINUE READING
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