Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling.

@article{Rallabhandi2008DifferentialAO,
  title={Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling.},
  author={Prasad V. Rallabhandi and Agnes Awomoyi and Karen E. Thomas and Armelle Phalipon and Yukari Fujimoto and Koichi Fukase and Shoichi Kusumoto and Nilofer Qureshi and Marcelo B. Sztein and Stefanie N. Vogel},
  journal={Journal of immunology},
  year={2008},
  volume={180 2},
  pages={1139-47}
}
The lipid A of LPS activates TLR4 through an interaction with myeloid differentiation protein-2 (MD-2) and the degree of lipid A acylation affects TLR4 responsiveness. Two TLR4 single nucleotide polymorphisms (Asp299Gly and Thr399Ile) have been associated with LPS hyporesponsiveness. We hypothesized that the combination of hypoacylation and these single nucleotide polymorphisms would exhibit a compounded effect on TLR4 signaling. HEK293T transfectants expressing wild-type or polymorphic TLR4… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

Similar Papers

Loading similar papers…