Differential activation of formyl peptide receptor signaling by peptide ligands.

@article{Bae2003DifferentialAO,
  title={Differential activation of formyl peptide receptor signaling by peptide ligands.},
  author={Y S Bae and Ji Young Song and Youndong Kim and Rong He and Richard D Ye and Jong-Young Kwak and Pann Ghill Suh and Sung Ho Ryu},
  journal={Molecular pharmacology},
  year={2003},
  volume={64 4},
  pages={841-7}
}
Formyl peptide receptor (FPR) and formyl peptide receptor like 1 (FPRL1) play important roles in inflammation and immunity. Stimulation of FPR and FPRL1 initiates a cascade of signaling events, leading to activation of various phagocyte responses, including chemotaxis, superoxide generation, and exocytosis. Trp-Lys-Tyr-Met-Val-d-Met-NH2 (WKYMVm) is a synthetic peptide that binds to and activates FPR and FPRL1. To develop agonists that selectively activate phagocyte functions and therefore… CONTINUE READING

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