Differential activation of c-fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia.

@article{Ness2008DifferentialAO,
  title={Differential activation of c-fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia.},
  author={Jayne M. Ness and Cary R Harvey and Jason D Washington and Kevin A. Roth and Steven L. Carroll and Jianhua Zhang},
  journal={Journal of neuroscience research},
  year={2008},
  volume={86 5},
  pages={1115-24}
}
Neonatal hypoxia-ischemia (HI) induces immediate early gene (IEG) c-fos expression as well as neuron death. The precise role of IEGs in neonatal HI is unclear. We investigated the temporal and spatial patterns of c-Fos expression in postnatal day 7 mice after unilateral carotid ligation and exposure to 8% oxygen. mRNA levels of c-fos quantitated by real-time polymerase chain reaction (PCR) increased nearly 40-fold (log 1.2 +/- 0.4) in the ipsilateral hippocampus 3 hr following neonatal HI, then… CONTINUE READING

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