Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat.

@article{Irving2000DifferentialAO,
  title={Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat.},
  author={E. Alexander Irving and Frank Barone and Alastair D. Reith and Sarah J Hadingham and Andrew A. Parsons},
  journal={Brain research. Molecular brain research},
  year={2000},
  volume={77 1},
  pages={65-75}
}
Two relatively well characterised kinase signalling pathways are those involving MAPK/ERK and p38/SAPK2, that are known to be activated in vitro by various factors known to increase following stroke, such as glutamate, IL-1 and TNF. The present study was designed to investigate the activation and cellular distribution of phosphorylated-ERK1/2, -p38 and the transcription factor CREB following focal cerebral ischaemia using phosphospecific antibodies. Up to 24 h following transient MCAO (90 min… CONTINUE READING
72 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 72 extracted citations

Similar Papers

Loading similar papers…