Differential activation of CRF receptor subtypes removes stress-induced memory deficit and anxiety.

@article{Todorovic2007DifferentialAO,
  title={Differential activation of CRF receptor subtypes removes stress-induced memory deficit and anxiety.},
  author={Cedomir Todorovic and Jelena Radulovic and Olaf Jahn and Marko Radulovic and Tessi Sherrin and Cathrin Hippel and Joachim Spiess},
  journal={The European journal of neuroscience},
  year={2007},
  volume={25 11},
  pages={3385-97}
}
The objective of this study was to investigate the role of corticotropin-releasing factor receptors 1 (CRF(1)) and 2 (CRF(2)) in anxiety-like behavior and learning of C57BL/6J mice after exposure to a stressful stimulus. When C57BL/6J mice were exposed to immobilization (1 h) serving as stressful stimulus, context- and tone-dependent fear conditioning were impaired if the training followed immediately after immobilization. The stress-induced impairment of context-dependent fear conditioning was… CONTINUE READING
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