Differential actions of the proneural genes encoding Mash1 and neurogenins in Nurr1-induced dopamine neuron differentiation.

@article{Park2006DifferentialAO,
  title={Differential actions of the proneural genes encoding Mash1 and neurogenins in Nurr1-induced dopamine neuron differentiation.},
  author={Chang-Hwan Park and Jin Sun Kang and Jae-Sang Kim and Seungsoo Chung and Jin-Young Koh and Eun-Hye Yoon and A Young Jo and M S Chang and H J Koh and Sejin Hwang and Haeyoung Suh-Kim and Yong-Sung Lee and Kwang-Soo Kim and Sang-Hun Lee},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 11},
  pages={2310-20}
}
The steroid receptor-type transcription factor Nurr1 has a crucial role in the development of the mesencephalic dopamine (DA) neurons. Although ectopic expression of Nurr1 in cultured neural precursor cells is sufficient in establishing the DA phenotype, Nurr1-induced DA cells are morphologically and functionally immature, suggesting the necessity of additional factor(s) for full neuronal differentiation. In this study, we demonstrate that neurogenic basic helix-loop-helix (bHLH) factors Mash1… CONTINUE READING