Differential actions of cardioprotective agents on the mitochondrial death pathway.

  title={Differential actions of cardioprotective agents on the mitochondrial death pathway.},
  author={Masaharu Akao and Brian O'Rourke and Hideo Kusuoka and Yasushi Teshima and Steven P Jones and Eduardo Marb{\'a}n},
  journal={Circulation research},
  volume={92 2},
We examined the effect of cardioprotective agents on three distinct phases of the H2O2-induced response that leads to loss of mitochondrial membrane potential (DeltaPsi(m)) and cell death in cultured cardiac myocytes: (1) priming, consisting of calcium-dependent morphological changes in mitochondria (swelling and loss of cristae), with preserved DeltaPsi(m), (2) depolarization, the rapid DeltaPsi(m) depolarization caused by mitochondrial permeability transition pore (PTP) opening, and (3) cell… CONTINUE READING


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