Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases.

@article{Klarenbach2003DifferentialAO,
  title={Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases.},
  author={Scott W. Klarenbach and Adam Chipiuk and Randy Nelson and Morley D Hollenberg and Allan G. Murray},
  journal={Circulation research},
  year={2003},
  volume={92 3},
  pages={272-8}
}
Endothelial cell proteinase activated receptors (PARs) belong to a family of heterotrimeric G protein-coupled receptors that are implicated in leukocyte accumulation and potentiation of reperfusion injury. We characterized the effect and the signal transduction pathways recruited after stimulation of endothelial PAR2. We used von Willebrand Factor (vWF) release and monolayer permeability to peroxidase to report Weibel-Palade body (WPB) exocytosis and pore formation, respectively. Human… CONTINUE READING
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