Differential action of cycloheximide and activation stimuli on transcription of tumor necrosis factor-alpha, IL-1 beta, IL-8, and P53 genes in human monocytes.

@article{Osipovich1993DifferentialAO,
  title={Differential action of cycloheximide and activation stimuli on transcription of tumor necrosis factor-alpha, IL-1 beta, IL-8, and P53 genes in human monocytes.},
  author={Oleg A. Osipovich and Konstantin V. Fegeding and Natalia I. Misuno and Tatiyana S Kolesnikova and I. K. Savostin and Andrew B. Sudarikov and Nikolai N. Voitenok},
  journal={Journal of immunology},
  year={1993},
  volume={150 11},
  pages={
          4958-65
        }
}
In the present study we have analyzed superinduction of TNF-alpha mRNA and enhancement of TNF-alpha gene transcription by cycloheximide (Chx) in human blood monocytes isolated by continuous Percoll gradient and activated in vitro. In the same monocyte cultures, we have compared the rate of gene transcription of TNF-alpha, IL-1 beta, IL-8, and the P53-antioncogene under the influence of plastic adherence, Staphylococcus aureus Cowan 1 (SAC), and Chx added at different times of monocyte culture… CONTINUE READING

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