Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins.

@article{Dietz2006DifferentialAL,
  title={Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins.},
  author={Megan L Dietz and Teresa M Bernaciak and Frank P. Vendetti and Joseph M. Kielec and Jeffrey D. Hildebrand},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 29},
  pages={20542-54}
}
Shroom is an actin-associated determinant of cell morphology that is required for neural tube closure in both mice and frogs. Shroom regulates this process by causing apical constriction of epithelial cells via a pathway involving myosin II. Here we report on characterization of the Shroom-related proteins Apxl and KIAA1202 and their role in cell architecture. Shroom, Apxl, and KIAA1202 exhibit differing abilities to interact with the actin cytoskeleton. In fibroblasts, Shroom readily… CONTINUE READING

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Conserved Activity of Shroom Family Proteins 20554 JOURNAL OF BIOLOGICAL CHEMISTRY

L. A. Linz-McGillem, M. C. andAlliegro
Eye Res • 2003
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