Differential TNF-signaling in chronic inflammatory disorders.

  title={Differential TNF-signaling in chronic inflammatory disorders.},
  author={Martin H. Holtmann and Markus F Neurath},
  journal={Current molecular medicine},
  volume={4 4},
TNF-alpha is a pleiotropic cytokine with strong proinflammatory and immunomodulatory properties. TNF-alpha plays a critical role in many acute or chronic inflammatory diseases and anti-TNF-strategies have proven to be clinically effective. Two TNF-specific cell surface receptors TNF-R1 and TNF-R2 have been identified and the function of these receptors and the downstream intracellular signal transduction pathways have been extensively studied in vitro. For a long time TNF-R1 was considered to… CONTINUE READING

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