Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?

  title={Differential TGF-\{beta\} signaling in retinal vascular cells: a role in diabetic retinopathy?},
  author={Rob J. Van Geest and Ingeborg Klaassen and Ilse M. C. Vogels and Cornelis J. F. van Noorden and Reinier Otto Schlingemann},
  journal={Investigative ophthalmology & visual science},
  volume={51 4},
Purpose. An early hallmark of preclinical diabetic retinopathy is thickening of the capillary basal lamina (BL). TGF-beta, a multipotent cytokine acting through its receptors ALK5 and -1, has been postulated to be involved in this phenomenon. In light of this possible role, TGF-beta signaling and its downstream molecular effects were characterized in cultured vascular endothelial cells and pericytes of the retina. Methods. Bovine retinal endothelial cells and pericytes were stimulated with TGF… CONTINUE READING


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