Differential T and B cell responses against Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin in infected healthy individuals and patients with tuberculosis.

@article{Masungi2002DifferentialTA,
  title={Differential T and B cell responses against Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin in infected healthy individuals and patients with tuberculosis.},
  author={Chantal Masungi and St{\'e}phane T. Temmerman and Jean-Paul Van Vooren and Annie Drowart and K{\'e}vin Pethe and Franco Menozzi and Camille Locht and Françoise Mascart},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={185 4},
  pages={
          513-20
        }
}
Because only 10% of individuals infected with Mycobacterium tuberculosis will eventually develop disease, antigens that are recognized differently by the immune systems of infected healthy and diseased subjects may constitute potential vaccine candidates. Here, the heparin-binding hemagglutinin adhesin (HBHA) is identified as such an antigen. Lymphocytes from 60% of healthy infected individuals (n=25) produced interferon (IFN)-gamma after stimulation with HBHA, compared with only 4% of patients… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 52 CITATIONS, ESTIMATED 52% COVERAGE

Characterization of diagnostic biomarkers for Mycobacterium tuberculosis infection

VIEW 7 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
HIGHLY INFLUENCED

Heparin-binding, hemagglutinin-specific IFN-gamma synthesis at the site of infection during active tuberculosis in humans.

  • American journal of respiratory and critical care medicine
  • 2010
VIEW 4 EXCERPTS
CITES METHODS, BACKGROUND & RESULTS
HIGHLY INFLUENCED

Regulatory T cells depress immune responses to protective antigens in active tuberculosis.

  • American journal of respiratory and critical care medicine
  • 2007
VIEW 6 EXCERPTS
CITES METHODS, RESULTS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2004
2018

CITATION STATISTICS

  • 8 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

Contribution of and CD8 T cells to g interferon production in human tuberculosis

H Shams, B Wizel, SE Wedis, B Samten, PF. Barnes
  • Infect Immun 2001;69:3497–501
  • 2001
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

Identification of a heparin-binding hemagglutinin present in mycobacteria

  • The Journal of experimental medicine
  • 1996
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Activation of human CD8 a b TCR cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway

DH Canaday, C Ziebold, +3 authors WH. Boom
  • J Immunol
  • 1999

Characterization of human Mycobacterium tuberculosis bacille Calmette-Guérin–reactive CD8 T cells

SM Smith, AS Malin, PT Lukey
  • Infect Immun
  • 1999
VIEW 1 EXCERPT