Differential Stabilities and Sequence-Dependent Base Pair Opening Dynamics of Watson–Crick Base Pairs with 5-Hydroxymethylcytosine, 5-Formylcytosine, or 5-Carboxylcytosine

Abstract

5-Hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) form during active demethylation of 5-methylcytosine (5mC) and are implicated in epigenetic regulation of the genome. They are differentially processed by thymine DNA glycosylase (TDG), an enzyme involved in active demethylation of 5mC. Three modified Dickerson-Drew… (More)
DOI: 10.1021/bi501534x

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@inproceedings{Szulik2015DifferentialSA, title={Differential Stabilities and Sequence-Dependent Base Pair Opening Dynamics of Watson–Crick Base Pairs with 5-Hydroxymethylcytosine, 5-Formylcytosine, or 5-Carboxylcytosine}, author={Marta W. Szulik and Pradeep S. Pallan and Boguslaw P. Nocek and Markus W Voehler and Surajit Banerjee and S. M. Brooks and Andrzej J. Joachimiak and Martin Egli and Brandt F Eichman and Michael P. Stone}, booktitle={Biochemistry}, year={2015} }