Differential Sensitivity of Naïve and Memory Subsets of Human CD8+ T Cells to TNF-α-Induced Apoptosis

  title={Differential Sensitivity of Na{\"i}ve and Memory Subsets of Human CD8+ T Cells to TNF-α-Induced Apoptosis},
  author={Sudhir Gupta and Houfen Su and Ruifen Bi and Sastry V. R. S. Gollapudi},
  journal={Journal of Clinical Immunology},
In this investigation, we have examined the relative sensitivity of human naïve, central memory (TCM), and two types of effector memory CD8+ T cells (TEM and TEMRA) to TNF-α-induced apoptosis. Our data show that naïve and TCM CD8+ T cells were sensitive, whereas TEM and TEMRA CD8+ T cells were relatively resistant to TNF-a-induced apoptosis. The apoptosis profile correlated with the activation of caspase-8 and caspase-3. However, no correlation was observed between relative sensitivity of four… CONTINUE READING
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