Differential Scales of Protein Quality Control

@article{Wolff2014DifferentialSO,
  title={Differential Scales of Protein Quality Control},
  author={Suzanne C. Wolff and Jonathan S. Weissman and Andrew G Dillin},
  journal={Cell},
  year={2014},
  volume={157},
  pages={52-64}
}
Proteins are notorious for their unpleasant behavior-continually at risk of misfolding, collecting damage, aggregating, and causing toxicity and disease. To counter these challenges, cells have evolved elaborate chaperone and quality control networks that can resolve damage at the level of the protein, organelle, cell, or tissue. On the smallest scale, the integrity of individual proteins is monitored during their synthesis. On a larger scale, cells use compartmentalized defenses and networks… CONTINUE READING
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