Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss

  title={Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss},
  author={David L. Boyle and Deepa R Hammaker and Meghan M Edgar and Mario M. Zaiss and Stefan Teufel and Jean Pierre David and Georg Schett and Gary S. Firestein},
  booktitle={PloS one},
Bone mass is maintained by osteoclasts that resorb bone and osteoblasts that promote matrix deposition and mineralization. Bone homeostasis is altered in chronic inflammation as well as in post-menopausal loss of estrogen, which favors osteoclast activity that leads to osteoporosis. The MAPK p38α is a key regulator of bone loss and p38 inhibitors preserve bone mass by inhibiting osteoclastogenesis. p38 function is regulated by two upstream MAPK kinases, namely MKK3 and MKK6. The goal of this… CONTINUE READING


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