Differential Roles of GABAA Receptor Subtypes in Benzodiazepine-Induced Enhancement of Brain-Stimulation Reward

@article{Reynolds2012DifferentialRO,
  title={Differential Roles of GABAA Receptor Subtypes in Benzodiazepine-Induced Enhancement of Brain-Stimulation Reward},
  author={Lauren M Reynolds and Elif Engin and Gabriella Tantillo and Hew Mun Lau and John W. Muschamp and William A Carlezon and Uwe Rudolph},
  journal={Neuropsychopharmacology},
  year={2012},
  volume={37},
  pages={2531-2540}
}
Benzodiazepines such as diazepam are widely prescribed as anxiolytics and sleep aids. Continued use of benzodiazepines, however, can lead to addiction in vulnerable individuals. Here, we investigate the neural mechanisms of the behavioral effects of benzodiazepines using the intracranial self-stimulation (ICSS) test, a procedure with which the reward-enhancing effects of these drugs can be measured. Benzodiazepines bind nonselectively to several different GABAA receptor subtypes. To elucidate… CONTINUE READING
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