Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin

@article{Sylman2016DifferentialRF,
  title={Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin},
  author={Joanna L. Sylman and Uranbileg Daalkhaijav and Ying Zhang and Elliot Gray and Parsa A. Farhang and Tiffany T. Chu and Jevgenia Zilberman-Rudenko and Cristina Puy and Erik Ian Tucker and Stephanie A. M. Smith and James H Morrissey and Travis W. Walker and Xiaolin Nan and Andr{\'a}s Gruber and O Jt Mccarty},
  journal={Annals of Biomedical Engineering},
  year={2016},
  volume={45},
  pages={1328-1340}
}
In the contact activation pathway of the coagulation, zymogen factor XII (FXII) is converted to FXIIa, which triggers activation of FXI leading to the activation of FIX and subsequent thrombin generation and fibrin formation. Feedback activation of FXI by thrombin has been shown to promote thrombin generation in a FXII-independent manner and FXIIa can bypass FXI to directly activate FX and prothrombin in the presence of highly negatively charged molecules, such as long-chain polyphosphates (LC… CONTINUE READING
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