Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.

  title={Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.},
  author={Joseph R. Maxwell and Yu Zhang and William A Brown and Carole L. Smith and Fergus Byrne and Mike Fiorino and Erin N Stevens and Jeannette Bigler and John A. Davis and James B. Rottman and Alison L. Budelsky and Antony Symons and Jennifer E Towne},
  volume={43 4},
Interleukin-23 (IL-23) and IL-17 are cytokines currently being targeted in clinical trials. Although inhibition of both of these cytokines is effective for treating psoriasis, IL-12 and IL-23 p40 inhibition attenuates Crohn's disease, whereas IL-17A or IL-17 receptor A (IL-17RA) inhibition exacerbates Crohn's disease. This dichotomy between IL-23 and IL-17 was effectively modeled in the multidrug resistance-1a-ablated (Abcb1a(-/-)) mouse model of colitis. IL-23 inhibition attenuated disease by… CONTINUE READING
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