Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages

@article{Chen1998DifferentialRF,
  title={Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages },
  author={Danica Chen and Xiaohui Ji and M. Harris and J Feng and Gerard Karsenty and A J Celeste and V Benezra Rosen and G Mundy and S Harris},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={142},
  pages={295 - 305}
}
Cumulative evidence indicates that osteoblasts and adipocytes share a common mesenchymal precursor and that bone morphogenetic proteins (BMPs) can induce both osteoblast and adipocyte differentiation of this precursor. In the present study, we investigated the roles of BMP receptors in differentiation along these separate lineages using a well-characterized clonal cell line, 2T3, derived from the mouse calvariae. BMP-2 induced 2T3 cells to differentiate into mature osteoblasts or adipocytes… CONTINUE READING