Differential Role of Poly(ADP-ribose) polymerase in D. discoideum growth and development

@inproceedings{Rajawat2011DifferentialRO,
  title={Differential Role of Poly(ADP-ribose) polymerase in D. discoideum growth and development},
  author={Jyotika Rajawat and Hina A Mir and Rasheedunnisa Begum},
  booktitle={BMC Developmental Biology},
  year={2011}
}
Poly(ADP-ribose) polymerase is evolutionarily conserved as a responder to various forms of stress. Though PARP's role in cell death is well addressed, its role in development and multicellularity is still an enigma. We have previously reported the role of PARP in oxidative stress induced delayed development of D. discoideum. In the current study we highlight the involvement of PARP during D. discoideum development. Oxidative stress affects expression of aca and cAR1 thus affecting aggregation… CONTINUE READING