Differential Role of Hippocampal cAMP-Dependent Protein Kinase in Short- and Long-Term Memory

@article{Vianna2000DifferentialRO,
  title={Differential Role of Hippocampal cAMP-Dependent Protein Kinase in Short- and Long-Term Memory},
  author={Monica Ryff Moreira Vianna and Luciana A. Izquierdo and Daniela Mart{\'i} Barros and Patr{\'i}cia Grolli Ardenghi and Patr{\'i}cia Peres Iucif Pereira and Cleverson Rodrigues and Beatriz Moletta and Jorge Horacio Medina and Ivan A. Izquierdo},
  journal={Neurochemical Research},
  year={2000},
  volume={25},
  pages={621-626}
}
One-trial step-down inhibitory (passive) avoidance training is followed by two peaks of cAMP-dependent protein kinase (PKA) activity in rat CA1: one immediately after training and the other 3 h later. The second peak relies on the first: Immediate posttraining infusion into CA1 of the inhibitor of the regulatory subunit of PKA, Rp-cAMPS, at a dose that reduces PKA activity during less than 90 min, cancelled both peaks. Long-term memory (LTM) of this task measured at 24 h depends on the two… CONTINUE READING