Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.

@article{Zhao2016DifferentialRO,
  title={Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.},
  author={Li-hua Zhao and Yanting Yin and Dehua Yang and Bo Liu and Li Hou and Xiaoxi Wang and Kuntal Pal and Yi Jiang and Yang Feng and Xiaoqing Cai and Antao Dai and Mingyao Liu and Ming-wei Wang and Karsten Melcher and Hongjiao Xu},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 29},
  pages={15119-30}
}
G protein-coupled receptors (GPCRs) from the secretin-like (class B) family are key players in hormonal homeostasis and are important drug targets for the treatment of metabolic disorders and neuronal diseases. They consist of a large N-terminal extracellular domain (ECD) and a transmembrane domain (TMD) with the GPCR signature of seven transmembrane helices. Class B GPCRs are activated by peptide hormones with their C termini bound to the receptor ECD and their N termini bound to the TMD. It… CONTINUE READING
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