Differential Requirement of CAAX-mediated Posttranslational Processing for Rheb Localization and Signaling

@inproceedings{Hanker2010DifferentialRO,
  title={Differential Requirement of CAAX-mediated Posttranslational Processing for Rheb Localization and Signaling},
  author={Ariella B. Hanker and Natalia K Mitin and Rhonda S. Wilder and Elizabeth P Henske and Fuyuhiko Tamanoi and Adrienne D. Cox and Channing J Der},
  booktitle={Oncogene},
  year={2010}
}
The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer and are attractive targets for anti-cancer drug discovery. Rheb is targeted to endomembranes via its C-terminal CAAX (C=cysteine, A=aliphatic, X=terminal amino acid) motif, a substrate for posttranslational modification by a farnesyl isoprenoid. After farnesylation, Rheb undergoes two additional CAAX-signaled processing steps, Ras converting enzyme 1 (Rce1)-catalyzed cleavage of the AAX residues… CONTINUE READING