Differential Repression of Alternative Transcripts: A Screen for miRNA Targets

  title={Differential Repression of Alternative Transcripts: A Screen for miRNA Targets},
  author={Matthieu Legendre and William Ritchie and Fabrice Lopez and Daniel Gautheret},
  journal={PLoS Computational Biology},
  pages={396 - 400}
Alternative polyadenylation sites produce transcript isoforms with 3' untranslated regions (UTRs) of different lengths. If a microRNA (miRNA) target is present in the UTR, then only those target-containing isoforms should be sensitive to control by a cognate miRNA. We carried out a systematic examination of 3' UTRs containing multiple poly(A) sites and putative miRNA targets. Based on expressed sequence tag (EST) counts and EST library information, we observed that levels of isoforms containing… CONTINUE READING


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