Differential Regulation of Self-reactive CD4+ T Cells in Cervical Lymph Nodes and Central Nervous System during Viral Encephalomyelitis

  title={Differential Regulation of Self-reactive CD4+ T Cells in Cervical Lymph Nodes and Central Nervous System during Viral Encephalomyelitis},
  author={Carine Savarin and C. Bergmann and D. Hinton and S. Stohlman},
  journal={Frontiers in Immunology},
  • Carine Savarin, C. Bergmann, +1 author S. Stohlman
  • Published 2016
  • Biology, Medicine
  • Frontiers in Immunology
  • Viral infections have long been implicated as triggers of autoimmune diseases, including multiple sclerosis (MS), a central nervous system (CNS) inflammatory demyelinating disorder. Epitope spreading, molecular mimicry, cryptic antigen, and bystander activation have been implicated as mechanisms responsible for activating self-reactive (SR) immune cells, ultimately leading to organ-specific autoimmune disease. Taking advantage of coronavirus JHM strain of mouse hepatitis virus (JHMV)-induced… CONTINUE READING
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